N-Butyl-N-(4-hydroxybutyl) Nitrosamine에 의해서 백서방광에 유발된 발암현상에 대한 항암제의 복강내 투여효과

Other Titles
Effect of Intraperitoneal Injection of Single Chemotherapeutic Agent on Rat Bladder Carcinogenesis Induced by N-Butyl-N-(4-hydroxybutyl) Nitrosamine
Authors
김상규박관규김천일이성준
Department
Dept. of Urology (비뇨의학); Dept. of Pathology (병리학)
Issue Date
1991
Citation
대한비뇨기과학회지, Vol.32(2) : 177-183, 1991
ISSN
2005-6737
Abstract
Chemotherapeutic agents were evaluated for their effect on the development of urinary bladder tumors, induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in female Sprague-Dawley rats. For 16 weeks, 0.05% BBN was administered orally, and then chemotherapeutic agents (adriamycin and cisplatin) were injected intraperitoneally for 12 weeks. In our preliminary experimental series, an experimental bladder tumor model induced by BBN was useful in evaluating the effectiveness of chemotherapeutic agents. Cisplatin appears to be effective in inhibiting precancerous histologic changes and carcinoma in rat urinary bladder mucosa by BBN. However, the effectiveness of adriamycin was inconclusive. Key word : Bladder tumor, BBN.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/38704
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
Keimyung Author(s)
김천일; 이성준; 박관규
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