자간전증에서 혈액응고 및 섬유소용해작용의 변동

Abstract

To investigate the alterations of clotting and fibrinolytic activities in preeclampsia, the platelet, fibrinogen, D-dimer, plasminogen, antithrombin III activity, α2-plasmin inhibitor and protein C were assayed. The peripheral venous blood was sampled from 20 normal pregnant women as control group and 35 preeclamptic pregnant women as study group in the third trimester. The age and maternal body weight revealed no statistical difference between control and study group. The gestational age was statistically different (p<0.001) between control (40.5±0.6 weeks) and study group (35.8±0.8 weeks), but all in the third trimester. The neonatal body weight was also statistically different (p<0.005) between control (3552.5±176.4g) and study group (2472.9±357.9g). There was no statistical difference between normal pregnancy and preeclampsia in D-dimer, plasminogen and protein C. The platelet count was decreased in preeclampsia compared with normal pregnancy, but statistically not significant. There was a decreasing tendnecy (p<0.1, p>0.05) of α2-plasmin inhibitor in preeclampsia (82.0±9.8%, n=25) compared with normal pregnancy (96.0 ±7.2 %). The fibrinogen showed statistically significant decrease (p<0.001) in preeclampsia.