임신 중 말초 혈액 내 B임파구, T임파구 및 그 아형의 변화

Abstract

Many studies have been performed to evaluate of lymphocyte subsets in pregnancy as well as functional aspects of cell mediated immunity during pregnancy. However, studies of circulating B lymphocyte, T lymphocyte and subsets during pregnancy have yield conflicting results. The aubhors evaluated the B lymphocyte, T lymphocyte and subsets at various stage of pregnancy and nonpregnant controls. As a group, pregnant women had significantly (p < 0.05) lower total lymphocyte component ratio in second trimester (20.8 ± 4.4 %) and third trimester (20.4 ± 5.5 %) than did controls (32.6 ± 8.2 %) and first trimester pregnant women. The mean absolute number of lymphocyte in pregnancy is 190.4 ± 540.9/mm3. Component ratio of B lymphocyte in pregnant women is 9.7 ± 2.6 % and mean absolute number is 188.8 ± 66.6/mm3, which are not significantly different compared with control group. Component ratio of T lymphocyte is significantly (p < 0.05) higher in second trimester pregnant women (86.2 ± 1.6 %) and third trimester pregnant women (86.0 ± 2.8 %) than first trimester pregnant women (79.2 ± 5.6 %) and nonpregnant control group (79.7 ± 3.1 %). Component ratio of T4 cells is significantly (p < 0.05) higher is second trimester pregnant women (47.8 ± 5.4 %) and third trimester pregnant women (47.0 ± 6.1 %) than control group (41.7 + 3.6 %) and first trimester pregnant women (40.7 ± 8.3 %). Absolute number of T4 cells is significantly (p , 0.05) higher in pregnant women (768.8 ± 261.2/mm) than control group (587.2 ± 149.9/mm). Component ratio of T8 cells is lower in first trimester pregnant women (36.9 ± 5.7 %) than control group (38.4 ± 3.2 %), but which is not significantly different. Absolute number of T8 cells is significantly (p < 0.05) higher in first trimester pregnant women(736.5 + 212.8/mm) than control group (539.4 ± 133.9/mm). T4/T8 ratio in pregnant women (1.21 ± 0.34) is not statistically different compared with control with control group (1.09 ± 0.14). T/B lymphocyte component ratio is significantly (p < 0