원인불명 반복자연유산 환자에서 B 임파구, T 임파구 및 아형의 변화

Abstract

The depressed cell-mediated immunity in pregnant women may play an important role in the protection of the fetus from rejection by the mother. In this of view, many studies have been performed to evaluated of lymphocyte subsets in recurrent spontaneous abortion women. However, because of the discordance in published data, auther have reevaluated peripheral blood T-lymphocyte, B-lymphocyte and subsets defined by monoclonal antibodies with immunobead method for 37 recurrent spontaneous abortion women and 30 normal healthy women. The results were as follows. No significant difference was observed in the component ratio of the B cell. The component ratio of T lymphocyte in study group(70.5±10.1%) was significantly decreased in control group(79.7±3.1%)(p<0.001). The component ratio of Null cell in study group(19.0±10.1%) was higher than control group(9.4±2.6%)(p<0.001). In the component ratio of T4 cell, no statistically difference were observed in both groups. In the component ratio of T8 cell, study group(28.4±9.5%) was significantly lower than control group(38.4±3.2%)(p<0.001). T4/ T8 ratio in the study group(1.58±0.70%) was significantly higher than control group(1.09±0.14%)(p<0.001). In the component ratio of T/B cell, no statistically differences were observed. In conclusion, decreased T8 cell component ratio and increased T4/ T8 component ratio may be play an important role in recurrent spontaneous abortion.