Triamcinolone Acetonide가 배양 켈로이드 섬유아세포의 G1 세포주기 관련 유전자 발현에 미치는 영향

Other Titles
EXPRESSION OF G1 CELL CYCLE RELATED GENES IN TRIAMCINOLONE ACETONIDE TREATED KELOID FIBROBLASTS
Authors
우상현설정현서성일백원기서민호Sang-Hyun WooJung-Hyun SeulSeong-Il SuhWon-Ki BaekMin-Ho Suh
Department
Dept. of Microbiology (미생물학)
Issue Date
1998
Citation
대한성형외과학회지, Vol.25(2) : 178-190, 1998
ISSN
1015-6402
Abstract
The effect of triamcinolone acetonide(TA) on the expression of Gl related genes was investigated the cultured keloid fibroblast. The addition of TA to the culture medium resulted in growth inhibition of keloid fibroblast. TA reduced the expression of cyclin A, B, E and cyclin dependent kinase(CDK) 2 mRNA, but unexpectedly, the expression of cyclin C, Dl and CDK4 mRAN was not affected significantly as compared with those of normal fibroblast. Expressions of p16, p21 and p27, the wellestabilished CDK-inhibitors, were also investigated. The level of p16 was not detected in both normal and keloid fibroblasts and the expression of p27 was significantly decreased in keloid fibroblast. The expression of p21 was dramatically increased in keloid fibroblast but not significantly changed in normal fibroblast. Also the expressions of p53 and pRb, the well known tumor suppressor genes, were increased by the addition of TA. These data suggested that the observed growth inhibitory effect of TA may be related to transcriptional inactivation of cyclin A, B, E and CDK2 and to the transcriptional activation of p21, but the mechanisms of unchanged expression of cyclin C, Dl and CDK4 mRNA remain to be elucidated. Key words: Triamcinolone acetonide ,Keloid ,Cell cycle
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/39070
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
Keimyung Author(s)
서성일; 백원기; 서민호
File in this Item
oak-bbb-1823.pdf(886.51 kB)Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE