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만성골수성백혈병의 이차적 핵형변화로서 ider(9)(q10)t(9;22)(q34;q11.2) 동반 1예

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Affiliated Author(s)
전동석전효진김재룡송홍석
Alternative Author(s)
Jeon, Dong SeokChun, Hyo JinKim, Jae RyongSong, Hong Suk
Journal Title
대한임상병리학회지
ISSN
1015-6445
Issued Date
1999
Keyword
Ider(9)(q10)t(922)(q34q11.2)Blast crisisChronic myeloid leukemia
Abstract
Although occasional patients with chronic myeloid leukemia (CML) have chromosomal changes
other than Philadelphia chromosome early in the disease, in typical cases the 9;22 translocation
remains the sole abnormality throughout the disease course in chronic phase. When disease progression
occurs, however, 75-80% develop additional chromosome aberrations. These secondary
changes sometimes precede the more aggressive manifestations hematologically and clinically
and thus may serve as valuable prognostic indicators. ider(9)(q10)t(9;22)(q34;q11.2) is very rare
and a recurrent chromosomal abnormality associated with acute lymphoblastic leukemias (ALL)
and lymphoblastic crisis of CML. And ider(9)(q10)t(9;22)(q34;q11.2) is a lymphoid-specific rearrangement
and the patients with this abnormality are of older age on average. They commonly
show pre-B cell lineage immunophenotype and L2 morphology. We report a case of ider(9)
(q10)t(9;22)(q34;q11.2) as secondary aberration in a patient with lymphoblastic crisis of CML.
ider(9)(q10)t(9;22)는 매우 드문 핵형으로서 림프구계 특이
적인 핵형 변화이며 주로 노령층에서, 그리고 pre-B 세포성 면역
표현형 및 FAB 분류상 L2형태를 특징으로 나타내는 핵형이다.
아직 국내 보고된 바 없었으며, 저자들은 만성골수성백혈병에서
림프구성 모세포발증기로 이행된 환자의 골수 염색체 분석상
t(9;22)(q34;q11.2) 및 이차적인 핵형으로 ider(9)(q10)t(9;22)
를 경험하였다. 환자의 핵형은 46,XY,t(9;22)(q34;q11.2)
[12]/46,XY,ider(9)(q10)t(9;22)(q34;q11.2), der(22)t(9;22)
(q34;q11.2)[10]/45,XY,-9,der(22)t(9;22)(q34;q11.2)[3]로 분
석되었다.
Alternative Title
ider(9)(q10)t(9;22)(q34;q11.2) as Secondary Karyotypic Aberration of Chronic Myeloid Leukemia
Department
Dept. of Laboratory Medicine (진단검사의학)
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
최귀전 et al. (1999). 만성골수성백혈병의 이차적 핵형변화로서 ider(9)(q10)t(9;22)(q34;q11.2) 동반 1예. 대한임상병리학회지, 19(2), 266–270.
Type
Article
ISSN
1015-6445
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39431
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
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