정상 성인에서 보툴리눔 독소 A 주사 후 신경생리학적 변화

Other Titles
Neurophysiological Changes after Botulinum Toxin A Injection in Normal Adults
Authors
박기영김현리김종민이소영
Department
Dept. of Rehabilitation Medicine (재활의학)
Issue Date
2002
Citation
대한재활의학회지, Vol.26(1) : 55-60, 2002
ISSN
1225-584X
Abstract
Objecive: To evaluate the neurophysiological changes after intramuscular botulinum toxin A (BTX-A) injection in normal adults. Method: Nine subjects were studied by electrophysiological measurements before and after the injections. BTX-A (5 IU, BotoxⓇ, Allergen, USA) was injected in the extensor digitorum brevis (EDB) muscles. Thereafter, electrophysiological measurement was followed up during 6 months. Results: The compound muscle action potential (CMAP) amplitude of injected EDB muscle decreased significantly for 8 weeks, a maximal decrement at 4 weeks after injection. CMAP peak area changes over time were nearly identical to those of CMAP peak amplitudes. The first/fourth amplitude change of CMAP with 3-Hz repetitive nerve stimulation decreased significantly for 8 weeks and the amplitude following post-exercise activation increased significantly after injection. There were no significant changes in F-wave amplitude and latency. Conclusion: Serial electrophysiological measurements after intramuscular BTX-A injection into EDB provide useful information for the neurophysiological change after injection.
Keywords
Botulinum toxin AElectrophysiological changeExtensor digitorum brevis
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/39474
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학)
Keimyung Author(s)
박기영; 이소영
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