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정상 성인에서 보툴리눔 독소 A 주사 후 신경생리학적 변화

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Affiliated Author(s)
박기영이소영
Alternative Author(s)
Park, Gi YoungLee, So Young
Journal Title
대한재활의학회지
ISSN
1225-584X
Issued Date
2002
Keyword
Botulinum toxin AElectrophysiological changeExtensor digitorum brevis
Abstract
Objecive: To evaluate the neurophysiological changes after
intramuscular botulinum toxin A (BTX-A) injection in
normal adults.
Method: Nine subjects were studied by electrophysiological
measurements before and after the injections. BTX-A (5 IU,
BotoxⓇ, Allergen, USA) was injected in the extensor digitorum
brevis (EDB) muscles. Thereafter, electrophysiological
measurement was followed up during 6 months.
Results: The compound muscle action potential (CMAP)
amplitude of injected EDB muscle decreased significantly
for 8 weeks, a maximal decrement at 4 weeks after injection.
CMAP peak area changes over time were nearly
identical to those of CMAP peak amplitudes. The first/fourth
amplitude change of CMAP with 3-Hz repetitive nerve
stimulation decreased significantly for 8 weeks and the amplitude
following post-exercise activation increased significantly
after injection. There were no significant changes in
F-wave amplitude and latency.
Conclusion: Serial electrophysiological measurements after
intramuscular BTX-A injection into EDB provide useful
information for the neurophysiological change after injection.
Alternative Title
Neurophysiological Changes after Botulinum Toxin A Injection in Normal Adults
Department
Dept. of Rehabilitation Medicine (재활의학)
Publisher
School of Medicine
Citation
박기영 et al. (2002). 정상 성인에서 보툴리눔 독소 A 주사 후 신경생리학적 변화. 대한재활의학회지, 26(1), 55–60.
Type
Article
ISSN
1225-584X
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39474
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학)
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