만삭아와 미숙아에서 24시간 식도 pH 검사를 이용한 위식도역류증의 연구

Abstract

Background : Gastroesophageal reflux is common in infants. The incidence of reflux in preterm infant has been reported to be higher than in fullterm infant. We perform this study to evaluate the gastroesophageal reflux in preterm infant and fullterm infant. Method : A continuous 24 hour esophageal pH monitoring was performed in 28 asymptomatic infant(16 preterm infants and 12 fullterm infants). Four parameters(reflux index, number of reflux episodes in 24 hours, number of reflux episodes＞5 minutes in 24 hours, and duration of the longest reflux episode) were analyzed by gestation and birth weight. Result : All four parameters were not different in the low birth weight infant group(birth weight＜2,500gm) compared with infant of birth weight≥2,500gm. In preterm infant group, mean reflux index was 3.08±6.84% ; number of reflux episodes in 24 hours was 85.94±145.99 ; number of reflux episodes longer than 5 minutes was 0.38±0.72 ; and duration of the longest reflux episode was 3.69±4.88 minutes. In fullterm infant group, mean reflux index was 9.42±8.98% ; number of reflux episodes in 24 hours was 190.58±158.27 ; number of reflux episodes longer than 5 minutes was 5.17±5.97 ; and duration of the longest reflux episode 16.58±15.41 minutes. Significant differences in reflux index, number of reflux episode longer than 5 minutes, and duration of the longest reflux episode were found between the preterm infant and fullterm infant. The number of reflux episodes in 24 hours was not different between preterm and fullterm infants. Conclusion : In continuous 24 hour esophageal pH monitoring, gastroesophageal reflux was more common in fullterm infant than preterm infant.