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정상임신 및 중증전자간증에서 혈장 Antithrombin Ⅲ의 변동

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Affiliated Author(s)
김택훈김종인서영욱
Alternative Author(s)
Kim, Taek HoonKim, Jong InSuh, Young Wook
Journal Title
대한주산의학회잡지
ISSN
1229-2605
Issued Date
1993
Keyword
Antithrombin IIIpreeclampsia severenormal pregnancy.
Abstract
Antithrombin Ⅲ is the major in vivo serine protease inhibitor and a sensitive indicator of excess clotting activity.
Some author reported that the level of plasma antithrombin Ⅲ level is unaltered during normal pregnancy and primigravida women with preeclampsia had both a significant and potential pathologic decline in antithrombin Ⅲlevel compared to either healty pregnant women or women with chronic hypertension.
To investigate the alterations of antithrombin Ⅲ level in normal pregnancy and severe preeclampsia and investigate the efficiency of antithrombin Ⅲ level in diagnosis and treatment of severe preeclampsia, plasma was sampled from 254 normal pregnancy women without pregnancy complications and hyperteneive condition until 72 hours after delivery and 46 severe preeclampstic women as study group and 35 nonpregnant healthy women were as control group.
There was statistically significant difference between normal pregnancy and severe preeclampsia in antithrombin Ⅲ level (P <0.0001).
The normal cutoff value of antithrombin Ⅲ was 21 mg/dl by ROC curve.
The specifitity, sensitivity, positive predictive value, negative predictive value, efficiency of antithrombin Ⅲ in diagnosis of severe preeclampsia showed 93 %, 78.3 %, 67.9 %, 96.0 %, 90.1 %.
Antithrombin Ill suggest a relatively good test for diagnosis of severe preeclampsia.
Alternative Title
Alteratione of Plasma Antithrombin Ⅲ in Normal Pregnancy and Severe Preeclampsia
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Publisher
School of Medicine
Citation
김택훈 et al. (1993). 정상임신 및 중증전자간증에서 혈장 Antithrombin Ⅲ의 변동. 대한주산의학회잡지, 4(4), 524–529.
Type
Article
ISSN
1229-2605
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/39610
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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