HaCaT 각질형성세포 및 섬유아세포에서 말기름의 항세균, 염증성 사이토카인 및 제 1형 교원질 발현에 대한 영향

Other Titles
Effect of Horse Oil on Anti-bacterial, Inflammatory Cytokines, and Type I Collagen Expressions in Human HaCaT Keratinocytes and Fibroblasts
Authors
최경화이영선윤지현유왕근김미려이규석조재위
Department
Dept. of Dermatology (피부과학)
Issue Date
2014
Citation
대한피부과학회지, Vol.52(1) : 1-6, 2014
ISSN
0494-4739
Abstract
Background: Anti-inflammation, anti-bactericidal, and collagen synthesis are important for health skin conditions. However, the effect of horse oil on anti-inflammation, anti-bactericidal, and collagen synthesis is largely unknown. Objective: The aim of this study was to evaluate the anti-bactericidal, anti-inflammatory, and synthesis of type I collagen of horse oil. Methods: Anti-bacterial effect was evaluated by disc diffusion test. Expressions of inflammatory cytokines were studied by RT-PCR analysis, real time PCR. Type I collagen expression was evaluated by Western blot in human HaCaT kertinocytes and fibroblasts. Results: Our data showed that horse oil exerted anti-bacterial effect on P.acnes and S.aureus. Expression of IL-10 was increased by horse oil-treated HaCaT cells. In addition, increased expression of type I collagen was observed in horse oil-treated human skin fibroblasts. Conclusion: Horse oil exerts an anti-bactericidal effect against P.acnes and S.aureus. In addition, anti-inflammatory and anti-aging effects of horse oil will be mediated by up-regulation of IL-10 and type I collagen, respectively.
Keywords
Anti-bactericidal effectHorse oilIL-10Type I collagen
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/39768
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
Keimyung Author(s)
이규석; 조재위
Full Text
http://kiss.kstudy.com/thesis/thesis-view.asp?key=3200753
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