기저세포암 및 편평세포암에서 Cyclin D1과 Bcl-xL의 발현

Other Titles
Expression of Cyclin D1 and Bcl-xL in Basal Cell Carcinoma and Squamous Cell Carcinoma
Authors
권준일김상표이규석조재위
Department
Dept. of Dermatology (피부과학); Dept. of Pathology (병리학)
Issue Date
2011
Citation
대한피부과학회지, Vol.49(3) : 234-241, 2011
ISSN
0494-4739
Abstract
Background: Cyclin D1 has a key function in cell proliferation. Bcl-xL has anti-apoptotic effects that can protect against cell death. However, it is still largely unknown whether these proteins play important roles in development of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Objective: The purpose of this study was to investigate the expression of cyclin D1 and Bcl-xL in both of these carcinomas. Methods: In this study, we examined expression levels of cyclin D1 and Bcl-xL in both carcinomas by immunohistochemistry, immunofluorescence and Western blot analysis. Results: We found increased expression of both proteins in BCC and SCC using immunohistochemistry. Moreover, expression of cyclin D1 and Bcl-xL were increased in both carcinomas relative to normal skin or seborrheic keratosis in Western blot analysis. BCC showed greater increases in expression of cyclin D1 and Bcl-xL on peripheral lesions compared to the center of tumor nests. Conclusion: That expression of cyclin D1 and Bcl-xL were increased in BCC and SCC, suggests that progression of the cell cycle combined with inhibition of apoptosis contributes to the carcinogenesis of BCC and SCC.
Keywords
Basal cell carcinomaBcl-xLCyclin D1Squamous cell carcinoma
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/39775
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
Keimyung Author(s)
이규석; 조재위; 김상표
Full Text
http://kiss.kstudy.com/thesis/thesis-view.asp?key=2902765
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