Fluorescein has been used for decades in ophthalmology for fluorescence angiography and it is the only fluorophore routinely used in experimental dermatology for in vivo study of the skin. It absorbs blue light, with peak absorption
and excitation wavelengths between 465 and 490 nm and fluoresces at yellow-green wavelengths of 520∼530 nm. The most common side effects are nausea and vomiting, and other adverse events such as a vasovagal response,
cardiac or respiratory effects, neurologic manifestations or allergy, including anaphylaxis, were also reported. But a photosensitive reaction to fluorescein is very rare. We report here on a case of photoallergic dermatitis due to
fluorescein after fluorescence angiography.