경피증양 피부 소견을 보인 유암 증후군 1예
- Affiliated Author(s)
- 김성애; 조재위; 이규석
- Alternative Author(s)
- Kim, Sung Ae; Cho, Jae We; Lee, Kyu Suk
- Journal Title
- 대한피부과학회지
- ISSN
- 0494-4739
- Issued Date
- 2009
- Keyword
- Carcinoid syndrome; Scleroderma; Serotonin
- Abstract
- Carcinoid syndrome exhibits a constellation of symptoms typically exhibited by patients with carcinoid tumors that produce neuroendocrine mediators, including serotonin. Carcinoid syndrome is diagnosed by increasing urinary 5-hydroxyindoleacetic acid and manifestations of gastrointestinal tract, respiratory, cardiovascular, and skin involvement, which occurs in <10% of patients. Cutaneous manifestations are flushing, telangiectasias, pellagra dermatitis, and
scleroderma-like lesions, which are relatively rare. A 60-year-old woman presented with sclerotic skin lesions on both legs. On examination, a 10×10 cm solid mass was palpable on the right lower abdomen, and she had facial
flushing and telangiectasia, but Raynaud's phenomenon was absent. The urinary 5-hydroxyindoleacetic acid was elevated (68.2 mg/day). Abdominal and pelvic CT scans showed a right ovarian tumor which was diagnosed as a carcinoid tumor by CT-guided needle biopsy. Thus, we report, for the first time, a case of carcinoid syndrome with scleroderma-like lesions in a Korean patient. If facial flushing and a scleroderma-like lesion present together, one should consider a carcinoid tumor.
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