신이식 환자에서 발생한 피부 병변

Abstract

Background : As the renal transplantation is rapidly becoming a standard treatment of end stage renal disease, a varieties of skin lesions in renal transplant recipients are being encountered in Korea. However, there have been little studies concerning the incidence and clinical feature of skin lesions has not been well addressed yet. Objective : We examined the skin manifestations in renal transplant recipients. Method : We attempted to assess the dermatologic problems in ５８ renal transplant recipients, who had been managed at Keimyung University Medical center between December, 2001, and July, 2002. Results : The results are summarized as follows; １. Among the ５８ patients, the number of male and female patients were ３１(５３.４%) and ２７(４６.６%)respectively. The men age was ３８.３ yews and the men duration of renal transplatant was ３８.７months. They had one more skin lesions. ２. Among the ５８ patients, skin infection was found in ６１(１０５%), drug-associated skin lesions in ３１(５３.４%), malignant skin turner in ０(０%) and other skin lesions in ６(１０.３%). ３. Viral infections were VZV infection(１５ cases, ２５.９%), HPV infection(１１ cases, １９%), HSV infection(７ cases, １２.１ %) and molloscum contagiosum(２ cases, ３.４%). Fungal infections were superficial mycosis(１６cases, ２７.６%) and deep mycosis(１ case, １.７%). Bacterial infection was found in ５(８.６%). ４. Drug-associated skin lesions were hypefrichosis(１７ cases, ２９.３%), acne(１１ cases, １９%), xerosis(７ cases, １２.１%), facial flusing, purpura and gingival hyperplasia(３ cases, ５.２%), respectively, telangiectasis and urticaria(２cases, ３.４%) respectively and alopecia(１ case, １.７%). ５. Other skin lesions included seborrheic dermatitis(８ cases, １３.８%), nummular dermatitis(３ cases, ５.２%), prurigo nodularis, scleredema, seborrheic keratosis and toxic erythema(１ case, １.７%). Conclusion : Long term use of immunosuppressive agents is associated with high incidences of skin disease. Education of patients and medical staff for early detection and treatment of skin lesions is important.