은나노 거즈의 피부 감염 세균에 대한 항균효과

Abstract

Background: The wound healing process is delayed by bacterial infection. Thus, proper prevention and treatment of infection are very important parts of wound healing. Silver has been used for wound dressing material due to its antimicrobial activities. Recently, a new nanochemistry technique made silver particles ＜20 nm in diameter, and this nanocrystalline silver can be used for dressing material. However, the antimicrobial effects of Nanosilver-coated gauze for bacterial skin infections are not well known. Objective: We investigated the antimicrobial activities of 3 Nanosilver-coated gauzes (1500Å, 800Å and 100Å) against known pathogens: Methicillin susceptible Staphylococcus aureus (MSSA), Methicillin resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (P. aeruginosa). Methods: The antimicrobial effects of Nanosilver-coated gauze on MSSA, MRSA and P. aeruginosa were tested using a disk diffusion method. Results: Nanosilver-coated gauzes of 1500Å and 800Å thicknesses showed antimicrobial activities against MSSA, implying susceptibility, while the 100Å Nanosilver-coated gauze showed intermediate activity. For MRSA and P. aeruginosa, 1500Å Nanosilver-coated gauze showed antimicrobial activities, but 800Å and 100Å Nanosilver-coated gauzes were not effective. Conclusion: The results suggest that a 1500Å thick Nanosilver-coated gauze has antimicrobial activities against MSSA, MRSA and P. aeruginosa in culture. Therefore, nanocrystalline silver may be a promising alternative dressing material for successful control of cutaneous infections.