Myeloperoxidase 결핍증 1례

Abstract

Myeloperoxidase(MPO) has an important role in killing of certain microorganisms, and hereditary myeloperoxidase deficiency has been described as an autosomal recessive leukocyte disorder associated with defective candidacidal activity in leukocytes. We experienced a case of rnyeloperoxidase deficiency in 60-year-old male patient with liver abscess and gall bladder stone. He presented with abdominal distension which appeared with fever, jaundice and RUQ pain. His WBC count was 35,640/μL with 92% neutrophils. The neutrophils showed D hle bodies, hypersegrnentation, ring-formed nuclei, hypogranulation lack of peroxidase activity and higher leukocyte alkaline phosphatase(LAP) score(146). In spite of intensive therapy with antibiotics for 7 days, he expired just after hopeless dicharge.