미만성 거대 B 세포 림프종에서 R-CHOP의 임상적 유효성
- Affiliated Author(s)
- 도영록; 송홍석
- Alternative Author(s)
- Do, Young Rok; Song, Hong Suk
- Journal Title
- 대한혈액학회지
- ISSN
- 1225-0546
- Issued Date
- 2004
- Keyword
- CHOP; Rituximab; B-cell lymphoma
- Abstract
- BACKGROUND: In combination with standard-dose CHOP (cyclophosphamide, vincristine, adriamycin, and prednisolone), the addition of rituximab produces a better clinical response in the treatment of aggressive B-cell non-Hodgkin´s lymphoma (NHL) than CHOP alone.
METHODS : Thirty-four patients with previously untreated diffuse large B-cell NHL received at least three or four cycles of rituximab 375 mg/m2 or 500 mg per dose on day 1 of each cycle in combination with CHOP chemotherapy.
RESULTS : The median age of patients were 61.5 years (range, 28-83 years). After the end of therapy, twenty-five patients (73.5%) experienced a complete response, four patients (11.8 %) had a partial response, and two patients (5.9%) were classified as having progressive disease. The median follow-up duration was 9.4 months (range, 0.2-19.5 months) and 1-year overall survival and progression free survival was 84.8+/-8.7% and 80.3+/-9.4%, respectively. Two patients (5.9%) experienced fever, myalgia, and skin eruption due to rituximab. Neutropenia of grade 3 or 4 occurred in thirty-one patients (91.2%).
CONCLUSION : The benefits of rituximab in combination with CHOP chemotherapy include high response rates and good tolerance. However, further prospective, randomized studies are needed to draw definitive conclusions.
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