유전분증이 동반된 비전형적 임상경과의 신증후성 출혈열 1례

Abstract

Hemorrhagic fever with renal syndrome(HFRS) is a symptom complex of fever, chill, myalgia, hemorrhagic diathesis and acute renal failure. We experienced a case of non-oliguric HFRS associated severe thrombocytopenia. Peripheral blood smear showed large atypical lymphocytosis and hemophagocytic histiocytes on bone marrow aspiration. Hantaan virus antibody titer was 1:5,120. Congo-red stain after potassium permanganate treatment of bone marrow biopsy revealed yellow-green birefringence and immunohistochemistry for AA amyloid antibody showed weak positive staining in the stroma of the bone marrow. Herein, we report a case of unusual HFRS associated with secondary amyloidosis and review the literature.