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제왕절개술을 위한 경막외마취시 Epinephrine의 혼합이 혈중 Lidocaine농도와 마취에 미치는 영향

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Affiliated Author(s)
장영호김애라전재규정정길
Alternative Author(s)
Jang, Young HoKim, Ae RaCheun, Jae KyuChung, Jung Kil
Journal Title
대한마취과학회지
ISSN
0302-5780
Issued Date
1994
Abstract
The effect of epinephrine on epidural biock and blood lidocaine concentration was investigated in women undergoing elective cesarean sections (n=24). Patients were randomly allocated to one of the two groups; one group received 2% lidocaine 20ml plain (group l, n=12), the other group received 2% lidocaine mixed with epinephrine 1 in 200,000 (group 2, n=12). Matemal venous blood samples were obtained 10, 20, 30, 45, 60 and 90 minutes following the injection. The mean blood concentration of lidocaine in group 2 was significantly lower than that of group 1, 20 minutes following the injection (P<0.05). The addition of epinephrine to the lidocaine solution reduced the peak blood concentration by 24% (from 3.93 to 3.01 ug/ml); however, this did not prolong the times at which the peak concentration was reached. The group 1 (plain) needed significantly more supplementary analgesia than group 2. The time from injection to Bromage scale 0 of group 2 (88.2±21.3 minutes) was significantly longer than that of group 1 (52.8±10.0 minutes). Incidence of matemal hypotension during operation, nausea/vomiting and shivering in the recovery, room did not differ significantly between the two groups. From this we came to the conclusion that epidural epinephrine reduces blood concentration of lidocaine and improves the duration and the quality of epidural anesthesia during cesarean sections.
Alternative Title
Effects of Epinephrine on Blood Concentration of Lidocaine and Epidural Block during Cesarean Section
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Publisher
School of Medicine
Citation
장영호 et al. (1994). 제왕절개술을 위한 경막외마취시 Epinephrine의 혼합이 혈중 Lidocaine농도와 마취에 미치는 영향. 대한마취과학회지, 27(5), 478–486. doi: 10.4097/kjae.1994.27.5.478
Type
Article
ISSN
0302-5780
DOI
10.4097/kjae.1994.27.5.478
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/40073
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
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