Vibrio vulnificus에 대한 항균제의 작용과 그 병합효과

Abstract

Thirty eight strains of Vibrio unlnificus isolated from various specimen were tested for antimicrobial susceptibility to 12 drugs by microdilution broth method. Against most of the strains tested, tetracycline (Tc), moxalactam (Mx), cefamandole (Cf), chloramphenicol (Cm), gentamicin (Gm0, cephalothin (Ct), and tobramycin (To) showed good antimicrobial effect, and streptomycin, ampicillin showed intermediate antibacterial effect or resistance. In order to search for combined antimicrobial activity between Tc and other drugs to Vibrio unlnificus, about 20 strains randomly activity with Tc, but Ct-Tc or To-Tc showed no antagonistic activity on all of strains tested, and they showed synergistic activity against 1 and 2 strains, respectiviely. These results suggest that single administration of Tc, Mx, Cf, Cm and Gm, or Tc-Ct and Tc-To combined medication can be useful for the treatment of Vibrio unlnificus infections. Key word : vibrio unlnificus, Antibiotics, Combination drug effect.