임상가검물에서 분리된 대장균의 Quinolone계 및 기타 항균제감수성

Abstract

A total of 165 strains of Escherichia coli which were isolated from urine(119), pus(14), wound (8), bile(6), throat(5)，catheter tip(5), and other clinical specimens, were tested for antimicrobial susceptibility to 21 drugs including 6 drugs of quinolones. The number of strains resistant to 16-11 drugs, 10-6 drugs, 5-1 drugs, were 16 strains(9.7%), 101 strains(61.2%), 40 strains(24.2%), respectively and number of strains sensitive to all drugs tested were 8(4.8%) strains. Moxalactam (Mx) was the most effective drugs and it inhibited growth of all strains at 2/μg/ml or less. One point eight to 0.6% of strains were resistant to erioxacin, ofloxacin (Of), pefloxacin, norfloxacin(Nf), ciprofloxacin(Cp), amikacin(Ak) and 13.9-6.1 % of strains were resistant to cefamandole, rifampin, tobramycin, nalidixic acid. Among these drugs, Nf, Cp, Of inhibited growth of all strains at 16μg/ml. However, 35.2-28.5% of strains were resistant to cephalothin, gentamycin, and majority of strains(91.5-57.5%) were resistant to penicillin, ampicillin, sulfisomidine, tetracycline, streptomy¬cin, chloramphenicol, trimethoprim, kanamycin. With these results, we consider that the useful drugs for the treatment of Escherichia coli infec¬tion were Mx, Ak, and quinolones. Key Words : Antimicrobial resistance, Escherichia coli.