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Anesthetic and Perioperative Management of Patient with Paroxysmal Nocturnal Hemoglobinuria

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Author(s)
Eun Kyung ChoiKwang Beom KimSang Jin ParkKi Bum Park
Publication Year
2018
Keyword
HemoglobinuriaHemolysisParoxysmalThrombosis
Abstract
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic
stem cell disorder. Surgery, anesthesia, infection, trauma, and pregnancy
can exacerbate hemolysis and thrombotic risk by increasing complement
activity. However, perioperative treatment of eculizumab can reduce risk
of hemolytic event by surgical stress. Here, we present the perioperative
clinical course and adequate anesthetic management of PNH complicated
by spine surgery under general anesthesia. We also describe a possible
role of eculizumab for PNH patients with anticipated high risks.
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.37(2) : 92-96-92-96, 2018
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/40366
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