Anesthetic and Perioperative Management of Patient with Paroxysmal Nocturnal Hemoglobinuria

Authors
Eun Kyung ChoiKwang Beom KimSang Jin ParkKi Bum Park
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Issue Date
2018
Citation
Keimyung Medical Journal, Vol.37(2) : 92-96-92-96, 2018
Abstract
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic stem cell disorder. Surgery, anesthesia, infection, trauma, and pregnancy can exacerbate hemolysis and thrombotic risk by increasing complement activity. However, perioperative treatment of eculizumab can reduce risk of hemolytic event by surgical stress. Here, we present the perioperative clinical course and adequate anesthetic management of PNH complicated by spine surgery under general anesthesia. We also describe a possible role of eculizumab for PNH patients with anticipated high risks.
Keywords
HemoglobinuriaHemolysisParoxysmalThrombosis
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/40366
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2018
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Keimyung Author(s)
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