Anesthetic and Perioperative Management of Patient with Paroxysmal Nocturnal Hemoglobinuria
- Affiliated Author(s)
- 박기범
- Alternative Author(s)
- Park, Ki Bum
- Journal Title
- Keimyung Medical Journal
- Issued Date
- 2018
- Keyword
- Hemoglobinuria; Hemolysis; Paroxysmal; Thrombosis
- Abstract
- Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic
stem cell disorder. Surgery, anesthesia, infection, trauma, and pregnancy
can exacerbate hemolysis and thrombotic risk by increasing complement
activity. However, perioperative treatment of eculizumab can reduce risk
of hemolytic event by surgical stress. Here, we present the perioperative
clinical course and adequate anesthetic management of PNH complicated
by spine surgery under general anesthesia. We also describe a possible
role of eculizumab for PNH patients with anticipated high risks.
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