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A primary gastric synovial sarcoma A case report and literature review

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Author(s)
조광범박경식류승완이유진이주엽강유나
Alternative Author(s)
Cho, Kwang BumPark, Kyung SikRyu, Seung WanLee, Yoo JinKang, Yu NaLee, Ju Yup
Issued Date
2017
Keyword
endoscopygastric neoplasmsynovial sarcoma
Abstract
RATIONALE:

When a gastric spindle cell tumor is observed, the possibility of synovial carcinoma, besides common mesenchymal tumor, should also be considered.

PRESENTING CONCERNS OF THE PATIENT:

The patient is a 51-year-old American woman who underwent medical check-up at a general hospital. Upper endoscopy showed a 2-cm sized mass covered with intact mucosa, and a central depression located on the posterior wall of the mid body. Biopsy of the mass showed focal atypical cells proliferation in mucosa on hematoxylin & eosin (H&E) staining. Endoscopic ultrasound showed a 17-mm homogenously hypoechoic mass within the submucosal layer.

INTERVENTIONS:

After diagnostic endoscopic submucosal dissection was performed, H&E and immunohistochemical staining showed synovial sarcoma (SS). To confirm the diagnosis, reverse transcriptase-polymerase chain reaction was performed, revealing a chimeric transcript of the SYT-SSX1 fusion gene. The diagnosis of primary gastric SS was confirmed because no evidence of possible primary lesions or metastatic lesions was observed. Therefore, the patient underwent distal gastrectomy.

OUTCOMES:

After surgery, the surgical specimen demonstrated no residual tumor cells. The patient received no adjuvant therapy, and there has been no evidence of local recurrence or distant metastasis for 2 months after the operation.

LESSONS:

When gastric subepithelial tumor is suspicious, we should also consider gastric SS.
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