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Analgesic effect of quetiapine in a mouse model of cancer-induced bone pain

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Author(s)
Mi Hwa HeoJin Young KimIlseon HwangEunyoung HaKeon Uk Park
Publication Year
2017
Keyword
MiceNeoplasmsNociceptorsPainQuetiapine fumarate
Abstract
BACKGROUND/AIMS:

Cancer-induced bone pain (CIBP) is one of the most common pains in patients with advanced neoplasms. Because of treatment-associated side effects, more than half of cancer patients are reported to have inadequate and undermanaged pain control. New mechanism-based therapies must be developed to reduce cancer pain. Quetiapine is a commonly used atypical antipsychotic drug. We report a study of the potential analgesic effects of quetiapine in a mouse model of CIBP and examine the mechanism of bone pain by analyzing the expression of various nociceptors.

METHODS:

Fifteen male C3H/HeN mice were arbitrarily divided into five groups: control and, CIBP with no treatment, quetiapine treatment, opioid treatment, and melatonin treatment. The mice were tested for mechanical hyperalgesia by determining the nociceptive hind paw withdrawal pressure threshold. Tissues from tibia were removed and subjected to quantitative and qualitative evaluations of transient receptor potential vanilloid 1 (TRPV1), TRPV4, acid-sensing ion channel 1 (ASIC1), ASIC2, and ASIC3 expression.

RESULTS:

Paw withdrawal pressure threshold was improved in the quetiapine treatment group compared with the CIBP group. Expression of TRPV1, TRPV4, ASIC1, ASIC2, and ASIC3 in the CIBP with quetiapine treatment group was significantly lower than that in the CIBP group.

CONCLUSIONS:

Our results suggest an analgesic effect of quetiapine in the CIBP animal model and implicate TRPV and ASICs as potential targets for cancer pain management.
Department
Dept. of Biochemistry (생화학)
Dept. of Internal Medicine (내과학)
Dept. of Pathology (병리학)
Publisher
School of Medicine (의과대학)
Citation
Korean Journal of Internal Medicine, Vol.32(6) : 1069-1074, 2017
Type
Article
ISSN
1226-3303
DOI
10.3904/kjim.2015.377
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/41065
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