Angelicin potentiates TRAIL-induced apoptosis in renal carcinoma Caki cells through activation of caspase 3 and down-regulation of c-FLIP expression

Authors
Kyoung-Jin MinHee Jung UmSeung Un SeoSeon Min WooShin KimJong-Wook ParkHyun-Shik LeeSang Hyun KimYung Hyun ChoiTae-Jin LeeTaeg Kyu Kwon
Department
Dept. of Immunology (면역학)
Issue Date
2018
Citation
Drug Development Research, Vol.79(1) : 3-10, 2018
ISSN
0272-4391
Abstract
Preclinical Research & Development Angelicin is a furocoumarin derived from Psoralea corylifolia L. fruit that has anti-inflammatory and anti-tumor activity. In the present study, the effect of angelicin in enhancing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptotic cell death was studied in Caki (renal carcinoma) cells. Angelicin alone and TRAIL alone had no effect on apoptosis, but in combination these compounds markedly induced apoptosis in the cancer cell lines while not inducing apoptosis in normal cells. The combination treatment induced accumulation of the sub-G1 population, DNA fragmentation, and activated caspase 3 activity in Caki cells, induced down-regulation of c-FLIP expression post-translationally, and over-expression of c-FLIP markedly blocked apoptosis induced by combined treatment with angelicin plus TRAIL. This study provides evidence that angelicin might be a TRAIL sensitizer.
Keywords
TRAILangelicinapoptosisc-FLIPcaspase
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/41070
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
Keimyung Author(s)
김신; 박종욱; 권택규
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