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Association Between Polymorphisms of Interleukin 1 Family Genes and Hepatocellular Carcinoma

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Affiliated Author(s)
신동훈이미영
Alternative Author(s)
Shin, Dong HoonLee, Mi Young
Journal Title
Medical Science Monitor
ISSN
1234-1010
Issued Date
2018
Keyword
CarcinomaHepatocellularInterleukin-1PolymorphismSingle Nucleotide
Abstract
BACKGROUND Hepatocellular carcinoma (HCC) is one of the most common malignancies occurring worldwide and is most frequent type of liver cancer. The risk for developing HCC increases with the severity of inflammation and fibrosis. The members of the interleukin-1 (IL-1) family are primarily proinflammatory cytokines due to their ability to stimulate the expression of genes associated with inflammation and autoimmune diseases. Several studies have suggested that some proinflammatory cytokines, such as the IL-1 family (IL-1α, IL-1β, and IL-1 receptor antagonist) are involved in the pathogenesis of HCC. MATERIAL AND METHODS This study aimed to determine whether polymorphisms in the IL-1 family of genes are associated with HCC. We analyzed 178 HCC patients and 397 controls to investigate the association between polymorphisms in IL-1α, IL-1β, and IL-1 receptor antagonist (IL-1RA) genes and HCC in the Korean population. All subjects were genotyped for the selected SNPs in IL-1α, IL-1β, and IL-1RA genes by Golden-Gate SNP Genotyping Assay. RESULTS Statistical analysis revealed a significant association at IL-1β between HCC and controls. Three individual polymorphisms (rs1143633, rs3917356, and rs1143627) were found to be associated with HCC. The SNPs of IL-1b gene (rs1143633A>G and rs1143627T>C) protected against HCC in the dominant model (p=0.027, OR=0.59, 95% CI=0.37-0.94; p=0.019, OR=0.56, 95% CI=0.34-0.91). The SNP of IL-1β gene (rs3917356G>A) increased the risk of HCC in the recessive model (p<0.001, OR=2.58, 95% CI=1.53-4.33), whereas other SNPs in IL-1α and IL-1RA showed no significant association between HCC patients and controls. CONCLUSIONS These results suggest that IL-1β in the IL-1 family contributes to HCC susceptibility.
Department
Dept. of Preventive Medicine (예방의학)
Publisher
School of Medicine (의과대학)
Citation
Ki Hong Tak et al. (2018). Association Between Polymorphisms of Interleukin 1 Family Genes and Hepatocellular Carcinoma. Medical Science Monitor, 24, 3488–3495. doi: 10.12659/MSM.907524
Type
Article
ISSN
1234-1010
DOI
10.12659/MSM.907524
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41082
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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