Association between White Matter Lesions and Cerebral Amyloid Burden in Patients with Cognitive Impairment
- Hyon-Ah Yi; Won, Kyoung Sook; Chang, Hyuk Won; Hae Won Kim
- Publication Year
- Introduction : White matter lesions (WMLs), detected as hyperintensities on T2-weighted MRI, represent
small vessel disease in the brain and are considered a potential risk factor for memory and
cognitive impairment in older adults. The purpose of this study was to evaluate the association
between WMLs and cerebral amyloid-β (Aβ) burden in patients with cognitive
Methods : A total of 83 patients with cognitive impairment, who underwent brain MRI and F-18 florbetaben
PET, were included prospectively: 19 patients were cognitively unimpaired, 30 exhibited
mild cognitive impairment (MCI), and 34 exhibited dementia. The Fazekas scale was used
to quantify WMLs on T2-weighted brain MR images. Cerebral Aβ burden was quantitatively
estimated using volume-of-interest analysis. Differences in cerebral Aβ burden were evaluated
between low-WML (Fazekas scale 1) and high-WML (Fazekas scale 2) groups.
The relationship between the Fazekas rating and cerebral Aβ burden was evaluated using
linear regression analysis after adjusting for age and sex.
Results : In the overall cohort, the high-WML group exhibited significantly higher Aβ burden compared
with the low-WML group (P = 0.011) and cerebral Aβ burden was positively correlated with
Fazekas rating (β = 0.299, P = 0.006). In patients with MCI, the high-WML group exhibited
significantly higher Aβ burden compared with the low-WML group (P = 0.019) and cerebral
Aβ burden was positively correlated with Fazekas rating (β = 0.517, P = 0.003).
Conclusion : The presence of WMLs was associated with cerebral Aβ burden in patients with MCI. Our
findings suggest that small vessel disease in the brain is related to Alzheimer's disease
- Authorize & License
- Files in This Item:
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.