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Association between White Matter Lesions and Cerebral Amyloid Burden in Patients with Cognitive Impairment

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Author(s)
Hyon-Ah YiWon, Kyoung SookChang, Hyuk WonHae Won Kim
Publication Year
2018
Abstract
Introduction : White matter lesions (WMLs), detected as hyperintensities on T2-weighted MRI, represent
small vessel disease in the brain and are considered a potential risk factor for memory and
cognitive impairment in older adults. The purpose of this study was to evaluate the association
between WMLs and cerebral amyloid-β (Aβ) burden in patients with cognitive
impairment.
Methods : A total of 83 patients with cognitive impairment, who underwent brain MRI and F-18 florbetaben
PET, were included prospectively: 19 patients were cognitively unimpaired, 30 exhibited
mild cognitive impairment (MCI), and 34 exhibited dementia. The Fazekas scale was used
to quantify WMLs on T2-weighted brain MR images. Cerebral Aβ burden was quantitatively
estimated using volume-of-interest analysis. Differences in cerebral Aβ burden were evaluated
between low-WML (Fazekas scale 1) and high-WML (Fazekas scale 2) groups.
The relationship between the Fazekas rating and cerebral Aβ burden was evaluated using
linear regression analysis after adjusting for age and sex.
Results : In the overall cohort, the high-WML group exhibited significantly higher Aβ burden compared
with the low-WML group (P = 0.011) and cerebral Aβ burden was positively correlated with
Fazekas rating (β = 0.299, P = 0.006). In patients with MCI, the high-WML group exhibited
significantly higher Aβ burden compared with the low-WML group (P = 0.019) and cerebral
Aβ burden was positively correlated with Fazekas rating (β = 0.517, P = 0.003).
Conclusion : The presence of WMLs was associated with cerebral Aβ burden in patients with MCI. Our
findings suggest that small vessel disease in the brain is related to Alzheimer's disease
pathology.
Department
Dept. of Nuclear Medicine (핵의학)
Dept. of Neurology (신경과학)
Publisher
School of Medicine (의과대학)
Citation
PLoS One, Vol.13(9) : e0204313-e0204313, 2018
Type
Article
ISSN
1932-6203
DOI
10.1371/journal.pone.0204313
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/41085
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