계명대학교 의학도서관 Repository

Asymmetry of cerebral glucose metabolism in very low-birth-weight infants without structural abnormalities

Metadata Downloads
Affiliated Author(s)
박재현김해원김천수원경숙
Alternative Author(s)
Park, Jae HyunKim, Chun SooWon, Kyoung SookKim, Hae Won
Journal Title
Plos One
ISSN
1932-6203
Issued Date
2017
Abstract
METHODS:

Thirty-six VLBW infants who underwent F-18 fluorodeoxyglucose (F-18 FDG) brain PET and MRI were prospectively enrolled, while infants with evidence of parenchymal brain injury on MRI were excluded. The regional glucose metabolic ratio and asymmetry index were calculated. The asymmetry index more than 10% (right > left asymmetry) or less than -10% (left > right asymmetry) were defined as abnormal. Regional cerebral glucose metabolism were compared between right and left cerebral hemispheres, and between the following subgroups: multiple gestations, premature rupture of membrane, bronchopulmonary dysplasia, and low-grade intraventricular hemorrhage.

RESULTS:

In the individual analysis, 21 (58.3%) of 36 VLBW infants exhibited asymmetric cerebral glucose metabolism. Fifteen infants (41.7%) exhibited right > left asymmetry, while six (16.7%) exhibited left > right asymmetry. In the regional analysis, right > left asymmetry was more extensive than left > right asymmetry. The metabolic ratio in the right frontal, temporal, and occipital cortices and right thalamus were significantly higher than those in the corresponding left regions. In the subgroup analyses, the cerebral glucose metabolism in infants with multiple gestations, premature rupture of membrane, bronchopulmonary dysplasia, or low-grade intraventricular hemorrhage were significantly lower than those in infants without these.

CONCLUSION:

VLBW infants without structural abnormalities have asymmetry of cerebral glucose metabolism. Decreased cerebral glucose metabolism are noted in infants with neurodevelopmental risk factors. F-18 FDG PET could show microstructural abnormalities not detected by MRI in VLBW infants
Department
Dept. of Pediatrics (소아청소년학)
Dept. of Nuclear Medicine (핵의학)
Publisher
School of Medicine (의과대학)
Citation
Jae Hyun Park et al. (2017). Asymmetry of cerebral glucose metabolism in very low-birth-weight infants without structural abnormalities. Plos One, 12(11), e0186976–e0186976. doi: 10.1371/journal.pone.0186976
Type
Article
ISSN
1932-6203
DOI
10.1371/journal.pone.0186976
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41087
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.