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Biological Aspect of Pathophysiology for Frozen Shoulder

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Affiliated Author(s)
조철현송광순김두환
Alternative Author(s)
Cho, Chul HyunSong, Kwang SoonKim, Du Hwan
Journal Title
BioMed Research International
ISSN
2314-6133
Issued Date
2018
Abstract
It is fairly well understood that frozen shoulder involves several stages, which reflect the series of process from capsular inflammation and fibrosis to spontaneous resolution of this fibrosis. However, the underlying pathophysiologic process remains poorly determined. For this reason, management of frozen shoulder remains controversial. Determining the pathophysiological processes of frozen shoulder is a pivotal milestone in the development of novel treatment for patients with frozen shoulder. This article reviews what is known to date about the biological pathophysiology of frozen shoulder. Although articles for the pathophysiology of frozen shoulder provide inconsistent and inconclusive results, they have suggested both inflammation and fibrosis mediated by cytokines, growth factors, matrix metalloproteinases, and immune cells. Proinflammatory cytokines and growth factors released from immune cells control the action of fibroblast and matrix remodeling is regulated by the matrix metalloproteinases and their inhibitors. To improve our understanding of the disease continuum, better characterizing the biology of these processes at clearly defined stages will be needed. Further basic studies that use standardized protocols are required to more narrowly identify the role of cytokines, growth factors, matrix metalloproteinases, and immune cells. The results of these studies will provide needed clarity into the control mechanism of the pathogenesis of frozen shoulder and help identify new therapeutic targets for its treatment.
Department
Dept. of Orthopedic Surgery (정형외과학)
Dept. of Rehabilitation Medicine (재활의학)
Publisher
School of Medicine (의과대학)
Citation
Chul-Hyun Cho et al. (2018). Biological Aspect of Pathophysiology for Frozen Shoulder. BioMed Research International, 2018, 7274517–7274517. doi: 10.1155/2018/7274517
Type
Article
ISSN
2314-6133
DOI
10.1155/2018/7274517
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41095
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학)
1. School of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학)
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