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Cadmium Exposure Is Associated with Monocyte Count and Monocyte to HDL Ratio, a Marker of Inflammation and Future Cardiovascular Disease in the Male Population

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Affiliated Author(s)
정인성
Alternative Author(s)
Chung, In Sung
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934
Issued Date
2017
Keyword
CadmiumCardiovascular DiseasesCholesterolHDLMonocytes
Abstract
Cadmium is a heavy metal that humans can be exposed to the in environment and occupation, and its relationship with cardiovascular diseases has been reported. in various reports. Epidemiological studies have also been associated with various inflammatory markers of cardiovascular diseases. In this study, we examined the relationship between monocyte count and monocyte to high density lipoprotein (HDL) ratio (MHR) and blood cadmium, which are one of the inflammatory markers of cardiovascular diseases. Data from a total of 733 male fire officers who received a health checkup at a hospital for one year in 2016 were analyzed. Populations were classified into 4 groups according to the quartile of blood cadmium and general characteristics were described. The relationship between monocyte count, MHR and cadmium in blood was statistically analyzed by linear regression analysis. In the univariate analysis and multivariate analysis, monocyte count was significantly higher in the second, third and fourth quartile groups than in the first quartile of cadmium, and the linear trend was significant. In univariate and multivariate analysis, MHR was significantly higher in the third and fourth quartile groups than in the first quartile group, and the linear trend was also significant. This study showed the significant relationship between blood cadmium and monocyte count and MHR among male fire officers. This was also statistically significant in the model adjusted for possible confounders and other cardiovascular risk factors and showed a linear trend.
Department
Dept. of Preventive Medicine (예방의학
Publisher
School of Medicine (의과대학)
Citation
Kiook Baek and Insung Chung. (2017). Cadmium Exposure Is Associated with Monocyte Count and Monocyte to HDL Ratio, a Marker of Inflammation and Future Cardiovascular Disease in the Male Population. Journal of Korean Medical Science, 32(9), 1415–1422. doi: 10.3346/jkms.2017.32.9.1415
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.2017.32.9.1415
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41103
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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