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dc.contributor.authorSeon Min Woo-
dc.contributor.authorSeung Un Seo-
dc.contributor.authorKyoung-jin Min-
dc.contributor.authorSeung-Soon Im-
dc.contributor.authorJu-Ock Nam-
dc.contributor.authorJong-Soo Chang-
dc.contributor.authorShin Kim-
dc.contributor.authorJong-Wook Park-
dc.contributor.authorTaeg Kyu Kwon-
dc.date.accessioned2019-03-11T16:32:12Z-
dc.date.available2019-03-11T16:32:12Z-
dc.date.issued2018-
dc.identifier.citationInternational Journal of Molecular Sciences, Vol.19(5) : e1309-e1309, 2018-
dc.identifier.issn1422-0067-
dc.identifier.otheroak-2018-0326-
dc.identifier.urihttp://kumel.medlib.dsmc.or.kr/handle/2015.oak/41161-
dc.description.abstractCorosolic acid is one of the pentacyclic triterpenoids isolated from Lagerstroemia speciose and has been reported to exhibit anti-cancer and anti-proliferative activities in various cancer cells. In the present study, we investigated the molecular mechanisms of corosolic acid in cancer cell death. Corosolic acid induces a decrease of cell viability and an increase of cell cytotoxicity in human renal carcinoma Caki cells. Corosolic acid-induced cell death is not inhibited by apoptosis inhibitor (z-VAD-fmk, a pan-caspase inhibitor), necroptosis inhibitor (necrostatin-1), or ferroptosis inhibitors (ferrostatin-1 and deferoxamine (DFO)). Furthermore, corosolic acid significantly induces reactive oxygen species (ROS) levels, but antioxidants (N-acetyl-l-cysteine (NAC) and trolox) do not inhibit corosolic acid-induced cell death. Interestingly, corosolic acid induces lipid oxidation, and α-tocopherol markedly prevents corosolic acid-induced lipid peroxidation and cell death. Anti-chemotherapeutic effects of α-tocopherol are dependent on inhibition of lipid oxidation rather than inhibition of ROS production. In addition, corosolic acid induces non-apoptotic cell death in other renal cancer (ACHN and A498), breast cancer (MDA-MB231), and hepatocellular carcinoma (SK-Hep1 and Huh7) cells, and α-tocopherol markedly inhibits corosolic acid-induced cell death. Therefore, our results suggest that corosolic acid induces non-apoptotic cell death in cancer cells through the increase of lipid peroxidation.-
dc.description.statementofresponsibilityopen-
dc.publisherSchool of Medicine (의과대학)-
dc.rightsBY_NC_ND-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/kr-
dc.subjectcorosolic acid-
dc.subjectlipid ROS-
dc.subjectnon-apoptotic cell death-
dc.subjectα-tocopherol-
dc.titleCorosolic Acid Induces Non-Apoptotic Cell Death through Generation of Lipid Reactive Oxygen Species Production in Human Renal Carcinoma Caki Cells-
dc.typeArticle-
dc.contributor.localauthor김신-
dc.contributor.localauthor임승순-
dc.contributor.localauthor박종욱-
dc.contributor.localauthor권택규-
dc.contributor.alternativelocalauthorIm, Seung Soon-
dc.contributor.alternativelocalauthorKim, Shin-
dc.contributor.alternativelocalauthorPark, Jong Wook-
dc.contributor.alternativelocalauthorKwon, Taeg Kyu-
dc.contributor.departmentDept. of Immunology (면역학)-
dc.contributor.departmentDept. of Physiology (생리학)-
dc.citation.volume19-
dc.citation.number5-
dc.citation.startpagee1309-
dc.citation.titleInternational Journal of Molecular Sciences-
dc.citation.endpagee1309-
dc.identifier.doi10.3390/ijms19051309-


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