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Current medical treatment of uterine fibroids

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Affiliated Author(s)
조치흠
Alternative Author(s)
Cho, Chi Heum
Journal Title
Obstetrics & Gynecology Science
ISSN
2287-8572
Issued Date
2018
Keyword
Uterine fibroidsGnRH receptor
Abstract
Uterine fibroids (leiomyomas or myomas), benign monoclonal tumors, are the most common benign tumors in
women. Heavy or prolonged menstrual bleeding, abnormal uterine bleeding, resultant anemia, pelvic pain, infertility,
and/or recurrent pregnancy loss are generally associated with uterine fibroids. Although curative treatment of this
tumor relies on surgical therapies, medical treatments are considered the first-line treatment to preserve fertility
and avoid or delay surgery. The aim of this review is to provide available and emerging medical treatment options
for symptomatic uterine fibroids. Literature review and consensus of expert opinion. Many uterine fibroids are
asymptomatic and require no intervention, although it is advisable to follow-up patients to document stability in
size and growth. Fibroid-associated symptoms include heavy menstrual bleeding and pain or pelvic discomfort. The
association between infertility and fibroids increases with age. Treatment options for symptomatic uterine fibroids
— include medical, surgical, and radiologically guided interventions. Various medical therapies are now available
for women with uterine fibroids, although each therapy has its own advantages and disadvantages. Currently,
gonadotrophin-releasing hormone (GnRH) agonists and selective progesterone receptor modulators (SPRMs) are
the most effective medical therapies, with the most evidence to support their reduction of fibroid volume and
symptomatic improvement in menstrual bleeding. The choice of treatment depends on the patient's personal
treatment goals, as well as efficacy and need for repeated interventions.
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Publisher
School of Medicine (의과대학)
Citation
Geum Seon Sohn et al. (2018). Current medical treatment of uterine fibroids. Obstetrics & Gynecology Science, 61(2), 192–201. doi: 10.5468/ogs.2018.61.2.192
Type
Article
ISSN
2287-8572
DOI
10.5468/ogs.2018.61.2.192
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41163
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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