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Diurnal variation of default mode network in patients with restless legs syndrome

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Affiliated Author(s)
조용원장혁원
Alternative Author(s)
Cho, Yong WonChang, Hyuk Won
Journal Title
Sleep Medicine
ISSN
1389-9457
Issued Date
2018
Keyword
Circadian rhythmDefault mode networkDiurnalResting state fMRIRestless legs syndrome
Abstract
OBJECTIVE:

Restless legs syndrome (RLS) patients compared to controls have been found to have abnormal patterns in the default mode network (DMN) in the morning when symptom threshold is the highest and symptoms are least likely to occur. If these morning abnormalities in DMN are pertinent to disease expression, then similar or further detectable differences may be expected on a nighttime assessment when RLS symptom threshold is at its lowest. The purpose of this study was to elucidate the potential neural mechanisms underlying the circadian aspect of RLS symptom expression by assessing diurnal changes in DMN.

METHODS:

Fifteen drug-naïve subjects with idiopathic RLS and 15 age- and gender-matched healthy subjects had fMRI scans in the morning and evening. The DMN patterns were compared both for differences between morning and evening and between RLS and controls.

RESULTS:

RLS patients compared to the healthy controls showed significant differences in morning and evening DMN. In particular, RLS patients showed consistent increased connectivity in the parietal lobule in both the morning and evening. In contrast, connectivity in the thalamus was increased in the morning and reduced in the evening. In addition, there were negative correlations between thalamic connectivity and the Korean versions of the international RLS scale and the quality-of-life subscore.

CONCLUSIONS:

The results indicated diurnal disturbances of the DMN in RLS subjects are consistent with both the circadian rhythm and severity of RLS. The circadian expression of RLS may relate to changes in arousal cortical-activation thresholds occurring with diurnal changes in the thalamic circuits of the DMN.
Department
Dept. of Neurology (신경과학)
Dept. of Radiology (영상의학)
Publisher
School of Medicine (의과대학)
Citation
Jeonghun Ku et al. (2018). Diurnal variation of default mode network in patients with restless legs syndrome. Sleep Medicine, 41, 1–8. doi: 10.1016/j.sleep.2017.09.031
Type
Article
ISSN
1389-9457
DOI
10.1016/j.sleep.2017.09.031
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41195
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
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