Etiology of Invasive Bacterial Infections in Immunocompetent Children in Korea (2006-2010): a Retrospective Multicenter Study

Authors
Kyuyol RhieEun Hwa ChoiEun Young ChoJina LeeJin Han KangDong Soo KimYae-Jean KimYoungmin AhnByung Wook EunSung Hee OhSung-Ho ChaYoung Jin HongKwang Nam KimNam Hee KimYun-Kyung KimJong-Hyun KimTaekjin LeeHwang Min KimKun Song LeeChun Soo KimSu Eun ParkYoung Mi KimChi Eun OhSang Hyuk MaDae Sun JoYoung Youn ChoiHoan Jong Lee
Department
Dept. of Pediatrics (소아청소년학)
Issue Date
2018
Citation
Journal of Korean Medical Science, Vol.33(6) : e45-e45, 2018
ISSN
1011-8934
Abstract
BACKGROUND: Invasive bacterial infections in apparently immunocompetent children were retrospectively analyzed to figure causative bacterial organisms in Korea. METHODS: A total of 947 cases from 25 university hospitals were identified from 2006 to 2010 as a continuance of a previous 10-year period study from 1996 to 2005. RESULTS: Escherichia coli (41.3%), Streptococcus agalactiae (27.7%), and Staphylococcus aureus (27.1%) were the most common pathogens in infants < 3 months of age. S. agalactiae was the most prevalent cause of meningitis and pneumonia and E. coli was the major cause of bacteremia without localizing signs in this group. In children 3 to 59 months of age, Streptococcus pneumoniae (54.2%), S. aureus (20.5%), and Salmonella spp. (14.4%) were the most common pathogens. S. pneumoniae was the leading cause of pneumonia (86.0%), meningitis (65.0%), and bacteremia without localizing signs (49.0%) in this group. In children ≥ 5 years of age, S. aureus (62.8%) was the predominant pathogen, followed by Salmonella species (12.4%) and S. pneumoniae (11.5%). Salmonella species (43.0%) was the most common cause of bacteremia without localizing signs in this group. The relative proportion of S. aureus increased significantly over the 15-year period (1996-2010) in children ≥ 3 months of age (P < 0.001), while that of Haemophilus influenzae decreased significantly in both < 3 months of age group (P = 0.036) and ≥ 3 months of age groups (P < 0.001). CONCLUSION: S. agalactiae, E. coli, S. pneumoniae, and S. aureus are common etiologic agents of invasive bacterial infections in Korean children.
Keywords
Bacterial InfectionsEpidemiologyEscherichia coliStaphylococcus aureusStreptococcus agalactiaeStreptococcus pneumoniae
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/41244
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
Keimyung Author(s)
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