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Jazf1 promotes prostate cancer progression by activating JNK/Slug

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Author(s)
Yonghun SungSong ParkSi Jun ParkJain JeongMinjee ChoiJinhee LeeWookbong KwonSoyoung JangMee-Hyun LeeDong Joon KimKangdong LiuSung-Hyun KimJae-Ho LeeYun-Sok HaTae Gyun KwonSanggyu LeeZigang DongZae Young RyooMyoung Ok Kim
Keimyung Author(s)
Lee, Jae Ho
Department
Dept. of Anatomy (해부학)
Journal Title
Oncotarget
Issued Date
2017
Volume
9
Issue
1
Keyword
JNKJazf1metastasisprostate cancerslug
Abstract
Juxtaposed with another zinc finger protein 1 (Jazf1) is a zinc finger protein and is known to affect both prostate cancer and type 2 diabetes. Jazf1 inhibits testicular nuclear receptor 4 (TR4) activation through protein-protein interaction, which results in weight loss and alleviates diabetes. However, the role of Jazf1 in prostate cancer is still poorly understood. Hence, we investigated whether the expression of Jazf1 is associated with prostate cancer progression. We confirmed the upregulation of Jazf1 expression in human prostate tissue samples. In addition, using Jazf1 overexpressing prostate cancer cell lines, DU145 and LNCaP, we found Jazf1 promoted cell proliferation and colony formation ability. We also observed that Jazf1 dramatically enhanced cell migration and invasion in transwell assays. Additionally, we checked the upregulation of vimentin and downregulation of E-cadherin expression in Jazf1-overexpressing DU145 and LNCaP cells. Moreover, we found that Slug, which is known to be regulated by JNK/c-Jun phosphorylation, was upregulated in the microarray analysis of two prostate cancer cell lines. Jazf1 promotes the phosphorylation of JNK/c-Jun, likely promoting cell proliferation and invasion through Slug. In a xenograft model, tumors overexpressing Jazf1 were larger than control tumors, and tumors with decreased Jazf1 were smaller. These data indicated that Jazf1 enhances prostate cancer progression and metastasis via regulating JNK/Slug signaling. Taken together, these results suggest that Jazf1 plays an important role in both androgen dependent and independent prostate cancer.
Keimyung Author(s)(Kor)
이재호
Publisher
School of Medicine (의과대학)
Citation
Yonghun Sung et al. (2017). Jazf1 promotes prostate cancer progression by activating JNK/Slug. Oncotarget, 9(1), 755–765. doi: 10.18632/oncotarget.23146
Type
Article
ISSN
1949-2553
DOI
10.18632/oncotarget.23146
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41324
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
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