Kahweol inhibits adipogenesis of 3T3-L1 adipocytes through downregulation of PPARγ
- Jin Soo Kim; Seul Gi Lee; Young Jin Kang; Taeg Kyu kwon; Ju-Ock Nam
- Dept. of Immunology (면역학)
- Issue Date
- Natural Product Research, Vol.32(10) : 1216-1219, 2018
- Kahweol, a compound from Coffea arabica, possesses antioxidant, anti-inflammatory, and antitumour properties. However, an anti-adipogenic effect has not yet been reported. In this study, we have shown that kahweol has an anti-adipogenic effect on 3T3-L1 adipocytes. Kahweol significantly inhibited the differentiation of intracellular lipid accumulation in 3T3-L1 adipocytes, without being cytotoxic. It also downregulated the expression of adipogenesis-related gene, including an adipocytokine, adiponectin. This anti-adipogenic effect stems from an ability to inhibit key adipogenic regulators, including PPARγ and C/EBPα. These results demonstrate that kahweol significantly inhibits the differentiation of 3T3-L1 cells, and suggest that it has potential as a novel anti-obesity treatment.
- 3T3-L1 adipocytes; Coffea arabica; PPAR; anti-adipogenic; kahweol
- Appears in Collections:
- 1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
- Keimyung Author(s)
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