Kahweol inhibits adipogenesis of 3T3-L1 adipocytes through downregulation of PPARγ

Authors
Jin Soo KimSeul Gi LeeYoung Jin KangTaeg Kyu kwonJu-Ock Nam 
Department
Dept. of Immunology (면역학)
Issue Date
2018
Citation
Natural Product Research, Vol.32(10) : 1216-1219, 2018
ISSN
1478-6419
Abstract
Kahweol, a compound from Coffea arabica, possesses antioxidant, anti-inflammatory, and antitumour properties. However, an anti-adipogenic effect has not yet been reported. In this study, we have shown that kahweol has an anti-adipogenic effect on 3T3-L1 adipocytes. Kahweol significantly inhibited the differentiation of intracellular lipid accumulation in 3T3-L1 adipocytes, without being cytotoxic. It also downregulated the expression of adipogenesis-related gene, including an adipocytokine, adiponectin. This anti-adipogenic effect stems from an ability to inhibit key adipogenic regulators, including PPARγ and C/EBPα. These results demonstrate that kahweol significantly inhibits the differentiation of 3T3-L1 cells, and suggest that it has potential as a novel anti-obesity treatment.
Keywords
3T3-L1 adipocytesCoffea arabicaPPARanti-adipogenickahweol
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/41325
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
Keimyung Author(s)
권택규
Full Text
https://www.tandfonline.com/doi/abs/10.1080/14786419.2017.1326039
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