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dc.contributor.authorJin Soo Kim-
dc.contributor.authorSeul Gi Lee-
dc.contributor.authorYoung Jin Kang-
dc.contributor.authorTaeg Kyu kwon-
dc.contributor.authorJu-Ock Nam -
dc.date.accessioned2019-03-11T16:34:26Z-
dc.date.available2019-03-11T16:34:26Z-
dc.date.issued2018-
dc.identifier.citationNatural Product Research, Vol.32(10) : 1216-1219, 2018-
dc.identifier.issn1478-6419-
dc.identifier.otheroak-2018-0660-
dc.identifier.urihttp://kumel.medlib.dsmc.or.kr/handle/2015.oak/41325-
dc.description.abstractKahweol, a compound from Coffea arabica, possesses antioxidant, anti-inflammatory, and antitumour properties. However, an anti-adipogenic effect has not yet been reported. In this study, we have shown that kahweol has an anti-adipogenic effect on 3T3-L1 adipocytes. Kahweol significantly inhibited the differentiation of intracellular lipid accumulation in 3T3-L1 adipocytes, without being cytotoxic. It also downregulated the expression of adipogenesis-related gene, including an adipocytokine, adiponectin. This anti-adipogenic effect stems from an ability to inhibit key adipogenic regulators, including PPARγ and C/EBPα. These results demonstrate that kahweol significantly inhibits the differentiation of 3T3-L1 cells, and suggest that it has potential as a novel anti-obesity treatment.-
dc.description.statementofresponsibilityprohibition-
dc.publisherSchool of Medicine (의과대학)-
dc.rightsBY_NC_ND-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/kr-
dc.subject3T3-L1 adipocytes-
dc.subjectCoffea arabica-
dc.subjectPPAR-
dc.subjectanti-adipogenic-
dc.subjectkahweol-
dc.titleKahweol inhibits adipogenesis of 3T3-L1 adipocytes through downregulation of PPARγ-
dc.typeArticle-
dc.contributor.localauthor권택규-
dc.contributor.alternativelocalauthorKwon, Taeg Kyu-
dc.contributor.departmentDept. of Immunology (면역학)-
dc.citation.volume32-
dc.citation.number10-
dc.citation.startpage1216-
dc.citation.titleNatural Product Research-
dc.citation.endpage1219-
dc.identifier.doi10.1080/14786419.2017.1326039-
dc.identifier.urlhttps://www.tandfonline.com/doi/abs/10.1080/14786419.2017.1326039-


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