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Long-term outcomes and recurrence patterns of standard versus extended pancreatectomy for pancreatic head cancer: a multicenter prospective randomized controlled study

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Affiliated Author(s)
강구정
Alternative Author(s)
Kang, Koo Jeong
Journal Title
Journal of Hepato-Biliary-Pancreatic Sciences
ISSN
1868-6974
Issued Date
2017
Keyword
Extended resectionLymph nodeNervePancreas cancerSurvival analysis
Abstract
BACKGROUND:
Our previous randomized controlled trial revealed no difference in 2-year overall survival (OS) between extended and standard resection for pancreatic adenocarcinoma. The present study evaluated the 5-year OS and recurrence patterns according to the extent of pancreatectomy.

METHODS:
Between 2006 and 2009, 169 consecutive patients were prospectively enrolled and randomized to standard (n = 83) or extended resection (n = 86) groups to compare 5-year OS rate, long-term recurrence patterns and factors associated with long-term survival.

RESULTS:
The surgical R0 rate was similar between the standard and extended groups (85.5 vs. 90.7%, P = 0.300). Five-year OS (18.4 vs. 14.4%, P = 0.388), 5-year disease-free survival (14.8 vs. 14.0%, P = 0.531), and overall recurrence rates (74.7 vs. 69.9%, P = 0.497) were not significantly different between the two groups, although the incidence of peritoneal seeding was higher in the extended group (25 vs. 8.1%, P = 0.014).

CONCLUSIONS:
Extended pancreatectomy does not have better short-term and long-term survival outcomes, and shows similar R0 rates and overall recurrence rates compared with standard pancreatectomy. Extended pancreatectomy does not have to be performed routinely for all cases of resectable pancreatic adenocarcinoma, especially considering its associated increased morbidity shown in our previous study.
Department
Dept. of Surgery (외과학)
Publisher
School of Medicine (의과대학)
Citation
Jin‐Young Jang et al. (2017). Long-term outcomes and recurrence patterns of standard versus extended pancreatectomy for pancreatic head cancer: a multicenter prospective randomized controlled study. Journal of Hepato-Biliary-Pancreatic Sciences, 24(7), 426–433. doi: 10.1002/jhbp.465
Type
Article
ISSN
1868-6974
DOI
10.1002/jhbp.465
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41336
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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