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Multi-institutional study of treatment patterns in Korean patients with WHO grade II gliomas: KNOG 15-02 and KROG 16-04 intergroup study

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Affiliated Author(s)
김엘김진희
Alternative Author(s)
Kim, ElKim, Jin Hee
Journal Title
Journal of Neuro-Oncology
ISSN
0167-594X
Issued Date
2018
Keyword
Low-grade gliomaPCVPatterns of careRadiotherapyTemozolomide
Abstract
INTRODUCTION:
We performed this study to identify the treatment patterns of patients with low-grade gliomas (LGG) in Korea.

METHODS:
A total of 555 patients diagnosed as WHO grade II gliomas between 2000 and 2010 at 14 Korean institutions were included. The patients were divided into four adjuvant treatment groups: adjuvant fractionated radiotherapy (RT, N = 204), adjuvant chemotherapy (N = 20), adjuvant fractionated RT and chemotherapy (N = 65), and non-adjuvant treatment (N = 266) groups. We examined differences among the groups and validated patient/tumor characteristics associated with the adjuvant treatments.

RESULTS:
Astrocytoma was diagnosed in 210 patients (38%), oligoastrocytoma in 85 patients (15%), and oligodendroglioma in 260 patients (47%). Gross total resection was performed in 200 patients (36%), subtotal resection in 153 (28%), partial resection in 71 patients (13%), and biopsy in 131 patients (24%). RT was most commonly applied as an adjuvant treatment. The use of chemotherapy with or without RT decreased after 2008 (from 38 to 4%). The major chemotherapeutic regimen was procarbazine, lomustine, and vincristine (PCV); however, the proportion of temozolomide increased since 2005 (up to 69%). Patient/tumor characteristics related with RT were male gender, non-seizure, multiple lobes involvement, and non-gross total resection. Chemotherapy was associated with non-gross total resection and non-astrocytoma.

CONCLUSIONS:
A preference for RT and increased use of temozolomide was evident in the treatment pattern of LGG. The extent of resection was associated with a decision to perform RT and chemotherapy. To establish a robust guideline for LGG, further studies including molecular information are needed.
Department
Dept. of Neurosurgery (신경외과학)
Dept. of Radiation Oncology (방사선종양학)
Publisher
School of Medicine (의과대학)
Citation
Taeryool Koo et al. (2018). Multi-institutional study of treatment patterns in Korean patients with WHO grade II gliomas: KNOG 15-02 and KROG 16-04 intergroup study. Journal of Neuro-Oncology, 138(3), 667–677. doi: 10.1007/s11060-018-2839-z
Type
Article
ISSN
0167-594X
DOI
10.1007/s11060-018-2839-z
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41360
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학)
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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