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Risk of mortality associated with human coronaviruses in adults

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Affiliated Author(s)
최원일박재석김현정박순효
Alternative Author(s)
Choi, Won IlPark, Jae SeokKim, Hyun JungPark, Sun Hyo
Journal Title
대한결핵및호흡기학회 추계학술발표초록집
Issued Date
2018
Keyword
Pneumonia, Coronavirus, Epidemiology
Abstract
Purpose: The purpose of the study is to describe seasonal and mortality differences of human coronaviruses (HCoVs) 229E and OC43 infection in adults. Materials and Methods: A retrospective cohort study was conducted on adult (≥18 years) patients admitted to the emergency department and ward of a university teaching hospital for suspected viral infection during Oct. 2012-Dec. 2017 (N=8,071). Respiratory viruses were detected in 1,689 patients using multiplex real-time polymerase chain reaction. Of those, 134 cases of HCoVs infection were detected including 12 cases mixed infection with other respiratory viruses. HCoV229E and OC43 single infection were 44 and 78 cases, respectively. The main outcome was 30-day all-cause mortality. Results: We identified 122 hospitalized adults with HCoVs infection without mixed infection. HCoVs 229E are predominantly detected in January and February, whereas OC43 (patterns - delete) occurred throughout the year. Sixteen hospitalized patients (13.1%) with HCoVs infection required admission to the ICU. Thirty-day all-cause mortality for 229E and OC43 was 22.7% and 11.5%, respectively. Patients infected with 229E seem to be more likely to die than those with OC43 after multivariate adjustment (OR 2.11, 95% CI 0.74-6.05). Conclusion: HCoVs infections of 229E and OC43 appear to have seasonally different patterns. 229E viral infection seems to be a more severe form than OC43 in adults.
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine (의과대학)
Citation
최원일 et al. (2018). Risk of mortality associated with human coronaviruses in adults. 대한결핵및호흡기학회 추계학술발표초록집, 126, 296–296.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41449
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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