Serum exosomal microRNAs as non-invasive biomarkers for human hepatocellular carcinoma

Authors
Gyeonghwa KimSe Young JangYu Rim LeeJung Gil ParkHye Won LeeSoo Young ParkWon Young TakYoung Oh KweonKeun Hur
Department
Dept. of Pathology (병리학)
Issue Date
2018
Citation
Journal of Extracellular Vesicles, Vol.7(suppl.1) : 241-241, 2018
ISSN
2001-3078
Abstract
Background: Although considerable progress has been made in the treatment of hepatocellular carcinoma (HCC), early detection is still highly considered the key to improved survival. Recently, cancer cellderived extracellular vesicles have been known to contain various intracellular biomolecules including microRNAs (miRNAs). The aim of this study was to evaluate whether exosomal miRNAs can serve as a serumbased biomarker in HCC. Methods: Expression of six miRNAs (miRNA-24, -130a, -182, -203, -373 and -423) was analysed in the exosome samples. We also investigated expression status of the six miRNAs in matched HCC tissues and corresponding normal liver tissues. Results: We observed that serum exosomal miRNA-203 (P < 0.05) and miRNA-373 (P < 0.05) were significantly up-regulated in advanced HCC patients. More interestingly, high serum exosomal miRNA-203 and miRNA-373 was associated with HCC progression (P < 0.01) as well as prognosis (P < 0.05) of HCC patients. Summary/Conclusion: We provided the novel evidence for usefulness of serum circulating exosomal miR-203 and miR-373 expressions as strong potential biomarkers for predicting prognosis and metastasis of HCC patients.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/41471
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
Keimyung Author(s)
이혜원
File in this Item
oak-2018-1010.pdf(103.8 kB)Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE