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The Association of Impaired Fasting Glucose and Serum Fibroblast Growth Factor-21 (FGF-21)

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Affiliated Author(s)
조호찬
Alternative Author(s)
Cho, Ho Chan
Journal Title
Diabetes
ISSN
0012-1797
Issued Date
2018
Abstract
Prediabetes includes impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and there is a strong probability that prediabetes will lead to diabetes mellitus (DM). Serum fibroblast growth factor 21 (FGF-21) is known to increase as a compensatory response to metabolic imbalance under conditions such as obesity, metabolic syndrome, and DM. This study aimed to identify the relationship of serum FGF-21 to prediabetes and to biomarkers of related metabolic diseases. Three hundred five Korean adult patients participated in a cohort study from June 2012 to December 2015. Study subjects comprised of those with normal glucose tolerance(n=165), prediabetes(IFG, IGT, n=87) and type 2 diabetes(n=54). The biochemical parameters were analyzed using auto-analyzer, and the level of FGF-21 was estimated using an ELISA kit. The analysis revealed that FGF-21 levels were significantly higher in the Prediabetes group compared to those in the normal group(193.94±10.62, 343.49±60.94)(P=0.004). One-way ANCOVA was conducted on the correlations between serum FGF-21 levels and other parameters, dyslipidemia(F=7.428, P=0.007), HbA1c(F=11.874, P=0.001) was show statistical significance.
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine (의과대학)
Citation
HANBYUL KIM and HOCHAN CHO. (2018). The Association of Impaired Fasting Glucose and Serum Fibroblast Growth Factor-21 (FGF-21). Diabetes, (suppl.1). doi: 10.2337/db18-184-LB
Type
Article
ISSN
0012-1797
DOI
10.2337/db18-184-LB
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41508
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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