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Clinical Outcomes of Kidney Transplantation in Patients With Biopsy-Proven Glomerulonephritis

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Author(s)
박성배한승엽진규복박우영박형섭
Alternative Author(s)
Park, Hyoung SeobHan, Seung YeupJin, Kyu BokPark, Woo YoungPark, Sung Bae
Issued Date
2018
Abstract
BACKGROUND:

The clinical outcomes after kidney transplantation (KT) according to the types of glomerulonephritis (GN) as the cause of end-stage renal disease (ESRD) are various, but there are not many studies on this.

METHODS:

Among 1,253 patients who had KT between November 1982 and January 2017, 183 recipients with biopsy-proven GN as the primary cause of ESRD were enrolled. We analyzed the incidence of recurrent GN and the factors associated with recurrence and graft and patient survivals.

RESULTS:

The types of GN were 95 IgA nephropathy, 47 focal segmental glomerulosclerosis, 14 membranous proliferative GN, 9 membranous GN, 8 lupus nephritis, 6 rapid progressive GN, and 4 Alport syndrome. The mean follow-up duration was 103 ± 81.7 months. Recurrence was reported in 36 patients, of which 20 grafts failed due to recurrence. The age of patients with GN recurrence was significantly younger than that of patients without GN recurrence (P = .030). The graft failure rate of KT recipients with recurrent GN was significantly higher than that of the recipients without recurrent GN (55.6% vs 18.4%, P < .001). In multivariate analysis, recurrence of primary GN, the number of HLA mismatches at AB, delayed graft function, and acute rejection were independent risk factors for graft failure.

CONCLUSION:

Recurrent GN remains a significant cause of graft loss in KT recipients. Surveillance of GN recurrence in the KT recipients with biopsy-proven GN can reduce allograft dysfunction.
Department
Kidney Institute (신장연구소)
Publisher
School of Medicine (의과대학)
Citation
Transplantation Proceedings, Vol.50(4) : 1009-1012, 2018
Type
Article
ISSN
0041-1345
DOI
10.1016/j.transproceed.2018.02.039
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/41511
Appears in Collections:
3. Research Institutues (연구소) > Kidney Institute (신장연구소)
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