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The effect of palonosetron on rocuronium-induced withdrawal movement

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Affiliated Author(s)
박기범
Alternative Author(s)
Park, Ki Bum
Journal Title
Revista Brasileira de Anestesiologia
ISSN
0034-7094
Issued Date
2017
Keyword
DorInjectionInjeçãoPainPalonosetronReflexo de retiradaRocuroniumRocurônioWithdrawal movement
Abstract
BACKGROUND:

Rocuronium causes pain and withdrawal movement during induction of anesthesia. In this study, palonosetron was investigated to have analgesic effect on the reduction of rocuronium-induced withdrawal movement.

METHODS:

120 patients were randomly assigned to one of three groups to receive either saline, lidocaine 20mg, or palonosetron 0.075mg with a tourniquet applied two minutes before thiopental sodium (5mg.kg-1) was given intravenously. After loss of consciousness, rocuronium (0.6mg.kg-1) was injected and the withdrawal movement was estimated by 4-point scale in a double-blind manner.

RESULTS:

The overall incidence of rocuronium withdrawal movement was 50% with lidocaine (p=0.038), 38% with palonosetron (p=0.006) compared with 75% for saline. The incidence of no pain to mild pain was significantly lower in the lidocaine and palonosetron groups (85% and 92% respectively) than in the saline group (58%). However, there was no significant difference in withdrawal movement between the lidocaine and palonosetron groups. There was no severe movement with palonosetron.

CONCLUSION:

Pretreatment of palonosetron with venous occlusion may attenuate rocuronium-induced withdrawal movement as effective as the use of lidocaine. It suggested that peripheral action of palonosetron was effective to reduce rocuronium-induced withdrawal movement.
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Publisher
School of Medicine (의과대학)
Citation
Ki-Bum Park et al. (2017). The effect of palonosetron on rocuronium-induced withdrawal movement. Revista Brasileira de Anestesiologia, 67(4), 337–341. doi: 10.1016/j.bjan.2016.04.010
Type
Article
ISSN
0034-7094
DOI
10.1016/j.bjan.2016.04.010
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41519
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
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