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The influence of vitamin C on the urine dipstck tests in the clinical specimens: a multcenter study

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Affiliated Author(s)
이원목
Alternative Author(s)
Lee, Won Mok
Journal Title
Journal of Clinical Laboratory Analysis
ISSN
0887-8013
Issued Date
2017
Keyword
interferenceurine dipstick testvitamin C
Abstract
BACKGROUND:

Vitamin C may interfere with the results of urine dipstick tests. We investigated the incidence of urinary vitamin C and its interference with urine dipstick reagents using a vitamin C dipstick.

METHODS:

The incidence of urinary vitamin C was determined in patients and healthy individuals undergoing routine medical check-ups. Interference tests were performed using samples with various amounts of added vitamin C. For clinical samples, we identified false-negative dipstick glucose, hemoglobin, and leukocyte esterase results based on the urine sediment and serum glucose results.

RESULTS:

Vitamin C was found in the urine of 18.1% of the subjects overall, and 23.1% of those undergoing medical check-ups. Dipstick results for glucose, leukocyte esterase, and hemoglobin differed between samples without vitamin C and with added vitamin C. When vitamin C was detected in clinical urine samples, 42.3%, 10.6%, and 8.2% of the glucose, hemoglobin, and leukocyte esterase dipstick tests were rated as false negative, respectively.

CONCLUSIONS:

Vitamin C was frequently found in clinical urine samples, and its concentration was higher in individuals undergoing medical check-ups. Urinary vitamin C can interfere with the urine dipstick results. This study gives useful information for predicting false-negative rates of urine dipstick tests caused by vitamin C.
Department
Dept. of Laboratory Medicine (진단검사의학)
Publisher
School of Medicine (의과대학)
Citation
Wonmok Lee et al. (2017). The influence of vitamin C on the urine dipstck tests in the clinical specimens: a multcenter study. Journal of Clinical Laboratory Analysis, 31(5), e22080–e22080. doi: 10.1002/jcla.22080
Type
Article
ISSN
0887-8013
DOI
10.1002/jcla.22080
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41531
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
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