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dc.contributor.author우선민-
dc.contributor.author권택규-
dc.date.accessioned2019-03-11T16:38:09Z-
dc.date.available2019-03-11T16:38:09Z-
dc.date.issued2018-
dc.identifier.citation생명과학회지, Vol.28(6) : 753-763, 2018-
dc.identifier.issn1225-9918-
dc.identifier.otheroak-2018-1420-
dc.identifier.urihttp://kumel.medlib.dsmc.or.kr/handle/2015.oak/41609-
dc.description.abstractCysteine cathepsins are lysosomal enzymes that belong to the papain family and can induce the degradation of damaged proteins through the endo-lysosomal pathway. It is highly upregulated in many cancers by regulating gene amplification and transcriptional, translational, and post-transcriptional modifications. Cathepsin S is part of the cysteine cathepsin family. Many studies have demonstrated that cathepsin S not only plays a specific role in MHC class II antigen presentation but also plays a crucial role in cancers. Cathepsin S is more stable at a neutral pH compared to other cysteine cathepsins, which supports the importance of cathepsin S in disease microenvironments. Therefore, the dysregulation of cathepsin S has participated in a variety of pathological processes, including cancer, arthritis, and cardiovascular disease. Furthermore, a decrease or depletion in the expression of cathepsin S has been implicated in the processes of tumor growth, invasion, metastasis, and angiogenesis. Taken together, cathepsin S has been suggested as an attractive therapeutic target for cancer therapy. In this review, the known involvement of cathepsin S in diseases, particularly with respect to recent work indicating its role in cancer therapy, is examined. An overview of current literature on the inhibitors of cathepsin S as a therapeutic target for cancer is also provided.-
dc.description.statementofresponsibilityopen-
dc.publisherSchool of Medicine (의과대학)-
dc.rightsBY_NC_ND-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/kr-
dc.subjectCancer-
dc.subjectcathepsin S-
dc.subjectcysteine cathepsin-
dc.subjectlysosome enzyme-
dc.subjectprotease-
dc.title암 치료 표적으로써 cathepsin S-
dc.title.alternativeCathepsin S as a Cancer Therapeutic Target-
dc.typeArticle-
dc.contributor.alternativeauthorSeon Min Woo-
dc.contributor.alternativeauthorTaeg Kyu Kwon-
dc.contributor.localauthor권택규-
dc.contributor.alternativelocalauthorKwon, Taeg Kyu-
dc.contributor.departmentDept. of Immunology (면역학)-
dc.citation.volume28-
dc.citation.number6-
dc.citation.startpage753-
dc.citation.title생명과학회지-
dc.citation.endpage763-
dc.identifier.doi10.5352/JLS.2018.28.6.753-


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