주의력결핍-과잉행동장애와 Corticotropin releasing hormone receptor 1 (CRHR1) 유전자 다형성의 관련성 연구

Abstract

Attention deficit hyperactivity disorder (ADHD) is known to be associated with a variety of risk factors, such as personal characteristics, psychosocial, neurologic, and physiological factor. Few studies have examined the genetic factors related to ADHD. In recent studies, ADHD may be associated to hypothalamus–pituitary–adrenal axis (HPA axis) activity. Corticotropin releasing hormone receptor 1 (CRHR1) gene is an important regulator of system of the HPA axis, we selected CRHR1 gene (rs110402) as candidated gene for ADHD. 107 ADHD patients and 106 normal newborns were used as frozen DNA. For analysis, CRHR1 (rs110402) gene was genotyped by Single strand conformation polymorphism analysis (SSCP). The genotype and allele distribution of CRHR1 (rs110402) gene polymorphism in ADHD group and normal control group were analyzed. As a result, ADHD and CRHR1 gene polymorphism showed significant differences in genotype and allele distribution. Plymorphism of CRHR1 may play an importatn role in ADHD in the Korean.