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Prevalence and Risk Factors of Functional Dyspepsia in Health Check-up Population: A Nationwide Multicenter Prospective Study

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Affiliated Author(s)
이주엽박경식
Alternative Author(s)
Lee, Ju YupPark, Kyung Sik
Journal Title
Journal of Neurogastroenterology and Motility
ISSN
2093-0887
Issued Date
2018
Keyword
DyspepsiaFemaleGastrointestinal disordersRisk factors
Abstract
Background/Aims
Functional dyspepsia (FD) is one of the most common gastrointestinal disorders, and FD imposes social and economic burden worldwide. The aim of this study is to identify the prevalence and risk factors of FD in health check-up population in tertiary centers in Korea.

Methods
A nationwide multicenter prospective study was performed at 9 tertiary healthcare centers in Korea between September 2016 and June 2017. A total of 2525 subjects were investigated based on endoscopic findings and questionnaires with the Rome III criteria, and Helicobacter pylori serology (IgG).

Results
A total of 1714 subjects without organic disease were enrolled. The mean (± SD) age was 51.5 (± 12.7) years, and 917 patients (53.5%) were female. The proportion of H. pylori seropositivity was 51.0% (874/1714). The prevalence of FD was 10.3% (176/1714), and the subtypes of postprandial distress syndrome alone, epigastric pain syndrome alone, and postprandial distress syndromeepigastric pain syndrome overlap were 4.8%, 3.0%, and 2.5%, respectively. Multivariate analysis showed that female gender (OR, 1.58; 95% CI, 1.14-2.21) and education below college level (OR, 1.45; 95% CI, 1.01-2.07) were related to FD. Multivariate analysis based on age 60 showed female gender as a significant (OR, 2.90; 95% CI, 1.06-7.94) factor in the group ≥ 60 years.

Conclusions
The prevalence of FD was 10.3% in the health check-up population in Korea. Female sex and education below college level were risk factors for FD. Female sex is a risk factor for FD in old age, underscoring the need for close attention in this age group.(J Neurogastroenterol Motil 2018;24:603-613)
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine (의과대학)
Citation
Sung Eun Kim et al. (2018). Prevalence and Risk Factors of Functional Dyspepsia in Health Check-up Population: A Nationwide Multicenter Prospective Study. Journal of Neurogastroenterology and Motility, 24(4), 603–613. doi: 10.5056/jnm18068
Type
Article
ISSN
2093-0887
DOI
10.5056/jnm18068
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41728
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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