Kahweol Ameliorates the Liver Inflammation through the Inhibition of NF- B and STAT3 Activation in Primary Kupffer Cells and Primary Hepatocytes

Authors
Hye-Young SeoMi-Kyung KimSo-Hee LeeJae Seok HwangKeun-Gyu ParkByoung Kuk Jang
Department
Dept. of Internal Medicine (내과학)
Issue Date
2018
Citation
Nutrients, Vol.10(7) : E863-E863, 2018
ISSN
2072-6643
Abstract
Gut derived bacterial endotoxins, such as lipopolysaccharide (LPS), are involved in one of the important mechanisms that lead to inflammation associated with various liver diseases, including nonalcoholic fatty liver disease and alcoholic liver disease. Kahweol is a coffee-specific diterpene present in coffee bean and exhibits anti-angiogenic and anti-inflammatory activities. However, to date, the effect of kahweol on liver inflammation remains unknown. In this study, we examined whether kahweol exhibits a protective effect by inhibiting liver inflammation in primary Kupffer cells and primary hepatocytes cultures as well as their co-cultures. Kahweol decreased the LPS-induced production of interleukin 1 alpha, interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha. The inhibitory effect of kahweol on the liver inflammation was associated with the down regulation of LPS-stimulated phospho-nuclear factor kappa B and -signal transducer and activator of transcription 3 expression. These results suggest that kahweol might be a novel potent agent to treat liver inflammation induced by LPS.
Keywords
liver inflammationlipopolysaccharidekahweolprimary hepatocyteprimary Kupffer cells
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/41730
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Keimyung Author(s)
김미경; 황재석; 장병국
Full Text
https://www.mdpi.com/2072-6643/10/7/863
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